Vaccine-Derived Polioviruses: Managing the Risks

This area of research focuses on managing the long-term risks of polio relating to vaccine-derived polioviruses (VDPVs) and vaccine-associated paralytic polio (VAPP) in the post-eradication era. It includes managing the risks through the eventual cessation of OPV use in routine immunization. In the first instance, this involves more clearly characterizing the risks of VDPVs (the risk of VAPP already being well-characterized).

Studies are under way to more clearly define the risks of VDPVs, including circulating VDPVs (cVDPVs), immunodeficiency-associated VDPVs (iVDPVs) and ambiguous VDPVs (aVDPVs). Vaccine-derived polioviruses can result from the continued re-introduction into the human population of the attenuated polioviruses contained in the oral polio vaccine.

Research is ongoing to understand how best to manage the VDPV risks, including through the cessation of OPV use in routine immunization programmes as soon as possible after certification of wild poliovirus eradication.

Environmental surveillance for poliovirus is being conducted in a number of countries including Australia, Egypt, Haiti and Indonesia. This area of research aims to further quantify the risk of circulating vaccine-derived poliovirus (cVDPV) emergence in countries that have recently switched from using oral polio vaccine to inactivated polio vaccine. Furthermore, these studies provide more evidence on the usefulness of environmental surveillance.

A series of studies are measuring the rate of long-term excretion of vaccine-derived poliovirus from immunodeficient people. The purpose is to better define the risk of immunodeficiency-related vaccine-derived polioviruses (iVDPVs).

Related Links


Related News

   01/07/2022
New guidance anticipated to quicken progress in achieving necessary safeguards
   28/06/2022
G7 and Commonwealth Heads of Government call for strengthened support to global polio eradication effort
   27/06/2022
Group issues recommendations to tackle both WPV1 outbreak in south-east Africa and variants across sub-Saharan Africa
   15/06/2022
Medical doctors and religious teachers play a crucial role in building trust and convincing families to vaccinate their children against polio
   13/06/2022
New report provides evidence on role of polio workforce in COVID-19 vaccine rollout and essential immunization, and makes the case to sustain the network to strengthen public health.