Vaccination campaigns

Children in Helmand, Afghanistan, show their inked fingers—a sign they have been vaccinated against polio. © WHO/Afghanistan — Children in Herat, Afghanistan, show their inked fingers—a sign they have been vaccinated against polio. © WHO/Afghanistan

From 21 to 23 April 2025, Afghanistan carried out its first nationwide polio vaccination campaign of the year, immunizing over 11 million children under five. The effort was synchronized with a similar campaign in neighbouring Pakistan—a vital strategy in what remains a race against time to stop poliovirus transmission in the last two endemic countries on earth.

Just four weeks later, Afghanistan implemented a second nationwide campaign in May, again synchronized with Pakistan. This back-to-back coordination is helping to close immunity gaps and intensify the fight against the virus ahead of the high transmission season.

Afghanistan and Pakistan form one epidemiological bloc, with interconnected polio transmission patterns and cross-border population movement meaning progress in one country is deeply linked to the other. Following a resurgence of wild poliovirus in 2024—paralyzing 99 children across both countries and expanding into both historic reservoirs and major urban centres—urgent, synchronized action has become more critical than ever.

The April and May campaigns in Afghanistan offered crucial opportunities to bolster immunity and prevent further spread of the virus. They followed earlier subnational campaigns in January and February, which focused on high-risk areas in the East, Southeast, and South Regions.

Despite a difficult operating environment, the Afghanistan polio eradication programme continues to adapt and innovate to protect every child. Since late 2024, the campaign modality in Afghanistan has shifted from house-to-house vaccination to a site-to-site approach, in which caregivers bring their children to designated vaccination sites to receive polio drops. While this change has introduced new challenges—particularly in ensuring high coverage in hard-to-reach communities—the programme is actively working to strengthen this approach as part of a broader “Strategic Reset.”

“The shift in modality requires new ways of working,” said Dr Mandeep Rathee, Polio Team Lead with WHO Afghanistan. “We are investing in strategies to ensure site-to-site campaigns are well-optimized and effective in reaching children who might otherwise be missed.”

East Region shows what’s possible

The East Region has emerged as a model of success. All districts in the region passed independent post-campaign monitoring using the Lot Quality Assurance Sampling (LQAS) method, indicating strong coverage and campaign quality. Revised microplans ensured that vaccination sites were placed closer to households—averaging fewer than four houses per site in line with Technical Advisory Group (TAG) recommendations.

This success has been underpinned by intensive community engagement, including the involvement of elders, religious leaders, and even children. Updated tools like child registration books and missed-child tracking formats have strengthened follow-up and accountability.

While these results demonstrate that site-to-site delivery can be effective when well planned and community-driven, global experience continues to show that house-to-house vaccination remains the most efficient strategy for achieving the highest levels of coverage—particularly in complex and high-risk settings. In the current context, the programme is focused on optimizing the tools and strategies available to reach every last child.

The success in the East is now informing similar efforts in other high-risk provinces, including the Central Region, where Farhad, a vaccinator based in Kabul, reflects on the importance of community engagement:

“On campaign day, I actively engage with community influencers including religious leaders, and encourage families to bring their eligible children to the site,” he said. “Community engagement and social mobilization are critical in the site-to-site modality.”

Parents like Jamal, who brought his four-year-old son to the site, echoed this appreciation: “Polio has no cure. Only the vaccine can protect our children. I’m grateful to the vaccinators who are here, even in difficult conditions, to make sure our children stay healthy.”

Strengthening routine immunization

In parallel, the programme is supporting efforts to strengthen routine immunization, particularly in areas where children may not be reached through all immunization efforts. In provinces such as Kandahar and Lashkargah, polio staff are helping to monitor routine Expanded Programme on Immunization (EPI) services, including at fixed and outreach sites—showcasing how polio infrastructure can support broader health system strengthening.

Reaching families through new approaches

During the April campaign, a new strategy to engage provincial and district governors, alongside community elders, was piloted in select districts. This approach helped improve community mobilization and inform local microplanning, and will be expanded in future rounds.

To further encourage attendance, the programme is offering essential hygiene items at vaccination sites. In Kandahar city, for example, more than 214,000 soaps and diapers were distributed during the February campaign—an approach that successfully increased turnout among caregivers of young children.

Coordinating across borders

Cross-border coordination with Pakistan is also being actively strengthened. Joint case investigations, monthly information-sharing meetings, and biannual national-level reviews are now in place. Following the recent influx of Afghan returnees, the programme activated a contingency plan to scale up vaccination along the border—supported by additional teams and close coordination with UNHCR and IOM.

These efforts are further reinforced by the Health Dialogue facilitated by WHO between Afghanistan and Pakistan—an example of how public health priorities advancing tangible action, even in fragile settings.

Every campaign counts

While challenges remain—including missed children, misinformation, and insecurity—the polio programme in Afghanistan is demonstrating that with commitment, adaptation, and strong community engagement, progress is possible.

“Every campaign brings us closer,” said Shamsher Ali Khan, UNICEF Chief of Polio in Afghanistan. “If we can continue to reach every child, we can end polio in Afghanistan—and across the region.”

28 February 2025, Jerusalem/Amman/Geneva – A five-day mass polio vaccination campaign in the Gaza Strip concluded on Wednesday, reaching nearly 603 000 children under 10 years of age with novel oral polio vaccine type 2 (nOPV2) following comprehensive, simultaneous access to all five governorates during the ongoing ceasefire. The campaign was conducted as part of emergency efforts to end an ongoing poliovirus outbreak and prevent further spread in the Gaza Strip.

During this round, an additional 40 000 children were vaccinated as compared to the previous two rounds conducted in September and October 2024, after poliovirus was detected in the Gaza Strip. The ceasefire enabled health workers to reach more children who had missed vaccinations due to displacement during the phased approach, living in areas that previously required special coordination for access, or being unreachable during the October 2024 round due to insecurity in North Gaza, including Jabalia, Beit Lahiya, and Beit Hanoun.

Strong community engagement and awareness of vaccination benefits had maintained high immunization rates in the Gaza Strip, where 89% of children received the third dose of oral polio vaccine in 2023, before the conflict. This round drew upon 1660 vaccination teams, 1242 of which were mobile, and deployed 1242 social mobilizers. Despite bad weather conditions, families welcomed the initiative and brought their children to points where they could receive the polio vaccine.

The campaign was conducted by the Palestinian Ministry of Health and implemented with support from the World Health Organization (WHO), the United Nations Children’s Fund (UNICEF), the United Nations Relief and Works Agency for Palestine Refugees (UNRWA), and other partners.

As part of the Global Polio Eradication Initiative’s commitment to mount a robust poliovirus outbreak response, surveillance for disease in children and for virus circulation in the environment has also been intensified since July 2024. It was this timely surveillance that detected ongoing environmental circulation of the virus, and the need to conduct additional vaccination to protect children.

As the ceasefire provides an opportunity to resume critical public health functions, working to recover Gaza’s previously strong disease surveillance and routine immunization are the best ways to protect children from polio and other vaccine-preventable diseases. Ending polio hinges on fully vaccinating every last child with polio vaccines. Ensuring uninterrupted access to safe water, sanitation and hygiene, and proper nutrition will protect children from many diseases including polio.

WHO, UNICEF and partners continue to call for a lasting ceasefire that leads to long-term health and peace.

17 February 2025, Jerusalem/Amman/Geneva – The emergency polio outbreak response in the Gaza Strip is continuing, with a mass vaccination campaign scheduled from 22 to 26 February 2025. The novel oral polio vaccine type 2 (nOPV2) will be administered to over 591,000 children under 10 years of age to protect them from polio. This campaign follows the recent detection of poliovirus in wastewater samples in Gaza, signaling ongoing circulation in the environment, putting children at risk .

Pockets of individuals with low or no immunity provide the virus an opportunity to continue spreading and potentially cause disease. The current environment in Gaza, including overcrowding in shelters and severely damaged water, sanitation, and hygiene infrastructure, which facilitates fecal-oral transmission, create ideal conditions for further spread of poliovirus. Extensive population movement consequent to the current ceasefire is likely to exacerbate the spread of poliovirus infection.

Two previous vaccination rounds in the Gaza Strip were successfully conducted in September and October 2024, reaching over 95% of the target. As poliovirus is found to remain in the environment, additional vaccination efforts are needed to reach every child and strengthen population immunity. The presence of the virus still poses a risk to children with low or no immunity, in Gaza and throughout the region.

In 2024, health workers faced significant challenges accessing certain areas of central, north and south Gaza, which required special coordination to enter during the conflict. In inaccessible areas such as Jabalia, Beit Lahiya, and Beit Hanoun where humanitarian pauses for the vaccination campaign were not assured, approximately 7,000 children missed vaccination during the second round. The recent ceasefire means health workers have considerably better access now.

No additional polio cases have been reported since a ten-month-old child was paralyzed in August 2024, but the new environmental samples from Deir al Balah and Khan Younis, collected in December 2024 and January 2025, confirm poliovirus transmission. The strain detected is genetically linked to the poliovirus detected in the Gaza Strip in July 2024.

The upcoming vaccination campaign aims to reach all children under 10 years of age, including those previously missed, to close immunity gaps and end the outbreak. The use of the oral polio vaccine will help end this outbreak by preventing the spread of the virus. An additional polio vaccination round is planned to be implemented in April.

The campaign will be led by the Palestinian Ministry of Health and implemented with support from the World Health Organization (WHO), United Nations Children’s Fund (UNICEF), United Nations Relief and Works Agency for Palestine Refugees (UNRWA) and other partners.

Polio vaccines are safe and there is no maximum number of times a child should be vaccinated. Each dose gives additional protection which is needed during an active polio outbreak.

WHO, UNICEF, and partners welcome the recent ceasefire and urge for a lasting ceasefire that leads to long-term peace.

Notes to editors: 

More information on the Global Polio Eradication Initiative, and daily updates on the outbreak response campaign, are available here (on this link, please scroll down the page to the list of polio-affected countries and click on ‘occupied Palestinian territory’).

Second round of polio campaign in Gaza completed amid ongoing conflict and attacks: UNICEF and WHO:https://www.emro.who.int/opt/news/second-round-of-polio-campaign-in-gaza-completed-amid-ongoing-conflict-and-attacks-unicef-and-who.html

Sitrep: https://polioeradication.org/wp-content/uploads/2024/05/ROUND-2-%E2%80%93-OUTBREAK-RESPONSE-SUMMARY.pdf

A vaccinator marking a child's little finger with ink to signify that he has been vaccinated against polio during the second round of the campaign at Mahamasina Market in Antananarivo, Madagascar. — A vaccinator marking a child’s little finger with ink to signify that he has been vaccinated against polio during the second round of the campaign at Mahamasina Market in Antananarivo, Madagascar.

Madagascar was certified free of wild poliovirus in June 2018 but since then has experienced outbreaks of type 1 variant polio. Between 2020 to 2023, 55 children in the country were paralyzed by the virus. But because of high-quality response activities, no new case has been reported since September 2023. This progress is thanks to the dedicated health workers who are committed to reaching every child with polio vaccines.

At the same time, the polio program recognizes that communities in Madagascar are facing numerous other health threats – neglected tropical diseases are chief among them. One of the most prevalent is lymphatic filariasis, commonly known as Elephantiasis, a disease caused by parasitic worms that can lead to extreme swelling of body parts, immense pain and severe disability. Infection is usually acquired during childhood, just like polio.

The good news is that its spread can be stopped by giving an annual dose of preventive chemotherapy to the at-risk population, a strategy called mass drug administration (MDA). The polio program, through its far-reaching house-to-house vaccination campaigns, has a lot of experience and infrastructure to do just that. The program is often a family’s only connection to the formal health system. As such, providing more services to these vulnerable households on each visit improves their trust in the program and health system, thus increasing the likelihood they will accept the vaccine.

Throughout 2023 and 2024, the Polio Coordination Team in Madagascar worked closely with the MDA Directorate to deliver this medicine alongside polio vaccines during their campaigns in response to the type 1 variant polio outbreak. The campaigns saw important improvements in coverage for both diseases. For example, during the last round of the 2023 campaign where 61 districts were targeted, only 2 had coverage lower than the 90-95% target for polio vaccination, and only 3 had coverage lower than the 65% target for MDA. In total, over 4.6 million children were protected from polio and lymphatic filariasis during the four rounds of the campaign in 2023. In the first and second rounds of the integrated campaign in 2024, about 1.4 million children were protected against polio and 1.2 million from lymphatic filariasis.

In addition to the ability to protect more children, there were also important financial savings for the health system. Thanks to the co-delivery of the two activities across 56 districts in 2023, there was an estimated cost savings of over US$ 1 million. In 2024, the integrated campaign in 15 districts was shown to have saved another US$ 172,000. Without integrating with the polio campaign, MDA would have likely been postponed for several months until adequate funds were mobilized, leaving thousands unprotected and vulnerable to the disease.

There are several key factors that have made these efforts so successful:

Government Commitment: The Madagascar government was committed to co-delivering polio and MDA to improve access to healthcare for its population and deliver more with less resources.
Strong Communication & Advocacy: The communications tools used during the campaigns by social mobilizers and the advocacy banners hung in communities also delivered integrated messages, including information on both polio and Elephantiasis.
Centralized Coordination: A single coordinating body of representatives from the MDA Directorate and the Polio Coordination team was formed, enabling easy sharing of resources to monitor preparations, train healthcare workers, and deploy them in the field. Strengthening the relationship between these teams at all levels facilitated helpful information sharing of best practices, improving both programs.
Agile Planning: The distribution of MDA was delayed by one day to ensure reduction of workload on the teams and assurance that any side effects could be monitored and correctly attributed.

The polio program in Madagascar, working closely with health authorities, will continue to optimize the delivery of other essential medicine and health services during campaigns. For example, a polio vaccination campaign in October 2024 also delivered measles vaccines to children.

As interruption of polio transmission gets closer in Madagascar, and outbreak response campaigns thus become less frequent, these efforts will increasingly focus on ways to strengthen routine immunization. Securing the resources and commitment to continue these efforts will be critical to both stopping polio now and building a stronger, more resilient health system to protect generations to come.

Female mobilizer vaccinators (FMVs) hosting a health education session in a village in Southeastern Afghanistan. The work of FMVs are pivotal in the country’s polio eradication efforts – they share important information on health, immunization, nutrition and hygiene, listen and alleviate the concerns of mothers and caregivers about vaccination, build trust, and vaccinate children against polio. © UNICEF

Spera clinic clings to a shaly mountainside in Khost province, in Afghanistan’s remote Southeast. In the shade of a walnut tree in the clinic’s leafy courtyard, Rezia clears her throat, and holds up a booklet of flip cards. Fifty women sit cross-legged at her feet, listening. The silence is broken only by children murmuring, and birds chirruping in the Spring morning.

Every day, Rezia delivers education sessions on a meticulous rota of topics relevant to the needs of the local women – nutrition, breastfeeding, general health and hygiene, and vaccination. This morning’s session is on the vaccine-preventable diseases that plague remote parts of the country – polio, measles and tetanus. Her rapt audience has walked miles to the clinic, some for two hours or more, carrying the smallest of their children. When Rezia pauses for breath, they waste no time in asking questions.

50 kilometres northeast, the town of Maidan sits in a lush valley where green ears of wheat bob in every spare patch of ground, a stone’s throw from the Pakistan border. In the district clinic, Spozmai is recording the day’s health education sessions in her register. Just today, she spoke to over a hundred women of all ages from the local community.

Rezia and Spozmai are part of the female mobilizer vaccinator (FMV) network – 656 women across Afghanistan whose daily work is to vaccinate children against polio and run health education sessions for women from the local community. In Khost, one FMV has been permanently assigned to every clinic for the last year. Each one is a member of the community she serves. Because of this, she has their ear. This is the FMVs’ superpower.

Maidan and Spera are in the so-called former “white areas”: parts of Afghanistan that, before August 2021, were inaccessible to outsiders, including other Afghans. The communities here are tight knit, self-sustaining and culturally conservative. After decades in isolation, trust is slow to build. This also extends to health care: turning these communities on to vaccination is painstaking work that is best done by an insider.

A girl in Khost Province, Southeastern Afghanistan, shows her marked finger after receiving the polio vaccination. The work of Female Mobiliser Vaccinators has bene crucial in reducing the number of children missing vaccination in the province. © UNICEF

As well as being one of the last two polio-endemic countries, Afghanistan is among the top twenty countries for ‘zero dose’ children globally. The Southeast has the highest number of children missed in the regular polio vaccination campaigns, especially in Khost and neighbouring Paktika. Paktika also has one of the lowest rates of routine immunization countrywide.[1]

It’s a universal human truth that we are less likely to listen to outside voices than we are to trusted members of our own communities. This is especially true for those who live in historically isolated areas. This includes attitudes toward vaccination – for measles and tetanus, but most of all for polio.

Changing people’s minds is the first, and biggest step toward reversing this trend, and women are critical players. “I’m respected in the community,” says Rezia. “I’m a mother, a grandmother – women listen to me. I can persuade the older women, and they want their daughters to have services they didn’t have. It trickles down.”

Afghan community structures are the framework along which information moves, how support is given, and how pressure is gently applied. To change attitudes and behaviours, you need to know how these structures fit together, and where to push. Rezia and Spozmai know who needs to be persuaded first to pass the message forward. Pass information to the right people and, like a drop of ink in water, it spreads.

According to the FMVs, the level of awareness among local women is a critical factor in bridging the immunization gap. Not just knowing when and why to vaccinate their children, but having their questions answered straightforwardly, and by a trusted neighbour, has contributed significantly to changing attitudes toward vaccination. Before the FMV programme began, health information was given by midwives or doctors, but this didn’t always work, especially if the doctor was a man. Rezia smiles: “Men can’t talk to us about things like this. And women wouldn’t listen if they tried.”

As the FMVs know well, change is coming slowly. As Spozmai says, “you can’t bring changes overnight.” Evidence of the impact of the FMVs’ work on vaccine acceptance in these insular parts of the country is to date mostly anecdotal, but copious, nonetheless. Certainly, the directors of clinics and hospitals in the polio high-risk regions of the South, East and Southeast attest to tangible changes in health seeking behaviours among their patient catchment populations since the programme began – especially among women.

When it comes to ending the grip polio and other vaccine-preventable diseases hold over Afghan communities and closing the gap on zero dose children, the FMVs’ role is critical. In health facilities in every corner of the country, these women are the mortar that is slowly filling the gap.

By Kate Pond, UNICEF Afghanistan

[1] From the forthcoming Knowledge, Attitudes and Practices of Polio in Afghanistan, UNICEF Afghanistan (December 2023).

Port Sudan, Sudan – Sudan’s Federal Ministry of Health (FMOH) will launch a polio vaccination campaign in April 2024 in response to a new emergence of variant poliovirus type 2 reported in January 2024. It was detected in six wastewater samples collected from September 2023 to January 2024 in the Port Sudan locality, Red Sea State.

The FMOH, with support from the World Health Organization (WHO), has completed field investigations and a risk assessment to determine the extent of the virus circulation. Preparations for a polio vaccination campaign in April 2024 in Red Sea, Kassala, Gedaref, River Nile, Northern, White Nile, Blue Nile and Sennar states are under way, with a differentiated approach for the rest of the states as conditions allow.

Read more on the WHO EMRO website.

My name is Farid, and I am 35 years old. I live in the Bati Kot district of Nangarhar province. I contracted polio when I was three years old. The symptoms started with a fever, then a weakness in my left leg and weakness in my left hand. While strength eventually returned to my hand, my leg remained weak. My parents took me to the doctor. After medical examinations, the doctors said that I had polio and there is no cure. When my parents heard that I could not be treated, they took me home.

Growing up with a paralyzed leg created many challenges for me. I couldn’t play with other children but I never lost hope. I fought to live my life like other children in my community. I started attending school, then completed my studies in computer science. My parents were always supportive, especially in my studies and building my career.

In my personal life, I also encountered challenges. When I wanted to get married, I faced rejection four times from different families. They did not want to marry their daughters to me because they said I have a disability and cannot work. I’m happy my wife’s family accepted me and I now have four beautiful children. I make sure to vaccinate my children at every opportunity. I don’t want them to be affected by poliovirus like I was. I also encourage my neighbors to vaccinate their children whenever they have the opportunity.

My daily life is challenging and I face many obstacles. There are certain tasks and jobs that my relatives, friends, and neighbors can do, but I cannot. I have some land in my village where I grow things like wheat and corn to help feed my family. Because my paralysed leg prevents me from cultivating my land, I pay someone to do this for me. This often brings me disappointment.

Because I know firsthand the danger of poliovirus and how it can affect the lives of children and their families, I joined the polio eradication programme in 2017. I work as a supervisor, and my job is to train vaccination teams under my supervision. I prepare them for vaccination campaigns, make sure they receive enough vaccines and equipment, monitor their work and report their achievements at the end of each day during the campaign. On campaign days, I go out and make sure all is working well for the teams, that they have everything they need and that all children in my area receive the polio vaccine.

For those who do not want to vaccinate their children, I go to their houses and tell them that the only way to protect their children from poliovirus is by vaccinating them with two drops of polio vaccine. I also tell them that if you don’t vaccinate your children, they could be paralysed like me. I share my personal story with them and challenges that I face in daily life. In our village, we used to have many vaccine refusals, but now they are few because I take the time to talk with parents and carers and explain my situation.

Even when we are not having vaccination campaigns, I talk with people and raise awareness about poliovirus and the importance of polio vaccine. We must vaccinate our children against polio at every opportunity. Polio is a terrible, crippling disease and we cannot let any child be paralysed.

Stopping any polio outbreak starts with vaccine procurement, transport by airplanes and trucks, distribution involving complex logistics, and eventually the oral administration of the vaccine by drops in the mouths of every eligible child.

However, there is another, lesser known but equally important process that must also take place to halt transmission of the poliovirus. It begins with a humble stool sample – a thumb-sized smudge of poop – taken from a child with acute flaccid paralysis (AFP), then delivered to the nearest laboratory that can test the sample specifically for poliovirus.

But nowhere in Yemen is there any such lab. So the long and arduous journey of any stool sample from a Yemeni child to a receiving lab can take up to several days – following an easterly route, to the neighboring country of Oman.

An explanation of how stool samples are transported over such a distance starts with why: monitoring children under 15 years of age for signs of AFP, which is the most common sign of poliovirus infection. The Global Polio Eradication Initiative has set a benchmark of at least three AFP cases per 100,000 children under 15 years of age, a standard that Yemen has consistently met, thanks to the effectiveness of its surveillance system. This achievement is all the more remarkable considering that Yemen is entering its ninth year of internal conflict, with resulting population displacements, widespread food and fuel shortages, and a devastated health system (in which only 46% of hospitals and health facilities are only partially functioning or completely out of service).

Read the rest of the story here.

Antananarivo – Quality assurance surveyor Anja Mandimbisoa arrives at a random lot numerically selected, throws her pen in the air, and whichever house it is pointing at when it lands is the next on her evaluation list. With their consent, she then sits down with the family to verify whether the children in the household have the mark on their little fingers confirming they have been vaccinated against polio.

“The fact that it is a random selection provides a true picture of immunization coverage at the district level,” explains Mandimbisoa, one of 16 external Lot Quality Assurance Sampling (LQAS) surveyors trained by World Health Organization (WHO) in Analamanga region, Madagascar, to identify any missed children.

As the country concludes its third round of polio vaccinations this year, the response reflects that the job to end polio does not end with the conclusion of a vaccination round. Instead, it is the actions between rounds that make all the difference.

Read more on the WHO AFRO website.

Islamabad – An announcement over a loudspeaker from the mosque captures the attention of parents and their children. The voice announces that a polio campaign is taking place in the settlement and vaccinators will be coming to give two drops to children under five. Eight teams of two vaccinators each are already on their way, each starting their day from the farthest house in the community and making their way to the center.

In January, when Pakistan detected a positive wild poliovirus from a sewage sample with genetic links to the virus circulating in Afghanistan, the polio teams jointly conducted a detailed epidemiological investigation to trace the routes of virus movement and identify infected populations. In a matter of weeks, a response was planned and implemented, vaccinating around 6.37 million children from 13 – 17 February. In this article we take you to an Afghan refugee settlement in Islamabad, one of the 30 districts that were covered partially and where the outbreak response focused on mobile and cross-border populations.

The story looks at three important components of a campaign: vaccinators, vaccines and tally sheets.

Vaccinators: the backbone of programme

“Who is there”, asks a man from inside the house, in Pushto.

“Polio team,” responds Salma who speaks Pushto. “We are here to give polio drops. Do you have children under five at home?”

A tall man with a three-year-old boy in his arms, opens the door and welcomes the two vaccinators. Salma introduces herself and her team member Amina and asks the father if either of their children had received polio drops that day. The father confirms that in this round, his children did not receive any polio drops.

“Can I give them the polio drops?”, asks Salma.

The father responded back energetically, “Of course, you can! I want my child to grow up healthy!”

This is when Salma opens the blue box. Inside it are ice packs and vials of oral polio vaccine. She talks to the little daughter and asks her to open her mouth and gives her two drops from the vial.

After giving the drops, she marks the girl’s little finger. “You can show this incase anyone asks if you got the polio drops.”

Amina, on the other hand, fills out the tally sheet that she will later submit to her supervisor. If this information is incorrect, it can impact the overall operational coverage data for the campaign.

On leaving the house, Amina takes out her chalk and marks the door of the house with key information that will mention what day they visited, the number of children under five in the house and if there was any child with symptoms of acute flaccid paralysis.

One house done, now on to the next one.

Vaccines: two drops for every child

“It is not always this straightforward,” says Amina. “Sometimes parents are skeptical about the vaccine and don’t want us to vaccinate their children. I often take the drops myself to show them how safe the vaccines are. When they see me taking these drops, it helps us build confidence with them.”

The polio programme has a long history of systematically listening to community concerns and addressing them, often engaging influencers such as religious leaders, to underscore the safety and efficacy of polio vaccines. This has helped address vaccine hesitancy and reached more children, building their immunity against this debilitating disease. At this settlement, occasional announcements were made through the mosque, informing people that a polio campaign was taking place and encouraging them to vaccinate their children. The result of these efforts has helped the programme significantly reduce the number of refusals across the country.

The blue box Amina carries with her has a large red “End Polio” sticker and it can carry up to 20 vaccine vials, nestled between the ice packs. Each vial contains 20 doses. She pays special attention to the box making sure the temperature is always maintained and the vaccines are kept out of direct sunlight. Vials that have been used, those that are unused and the ones in use are all kept in separate bags in the cold box.

Tally Sheets: supporting real-time corrective actions

The third important piece of a polio campaign is the tally sheet. In rudimentary terms, it is a piece of paper with many tiny boxes that deliver a telling story of number and ages of children, those who were vaccinated, those who were missed, location where the campaign is taking place and number of doses delivered. In case of any refusals, the vaccinator mentions the reason for refusal at the back of the tally sheet. It tells how well an area has been covered and the remaining gaps.

Markings on a house entrance after visitation by polio vaccinators. © WHO/EMRO

The authenticity of this data is a crucial component of operational coverage. It allows supervisors to identify gaps, present progress and advise corrective actions for vaccination teams. Each evening, this data is used to measure the campaign’s operational coverage.

In one of the houses where the vaccinators entered, the mother mentioned that the child had already been vaccinated. However, no finger of the child was marked , while the others each had a blue mark on their pinky finger. Taking no chances, the vaccinator took out the vial and gave the child drops and then marked the finger. The tally sheet cannot be marked unless a child has been vaccinated and finger-marked.

Getting past the finish line

Up until April, Pakistan has conducted four polio vaccination campaigns. With the support of 390,000 polio workers, almost 43 million children under-five were vaccinated during a five-day nationwide vaccination campaign. There are multiple campaigns planned for the year ahead, requiring hours of strategic and evidence-based planning led by the national and provincial emergency operations centres.

Leaving nothing to chance during this last 100 meter dash towards eradication, the programme has also started implementing innovative interventions, such as the nomad population mapping and vaccination of high-risk mobile populations, engaging public health students for monitoring campaigns through the Lot Quality Assurance Sampling survey and the co-design initiative that engages women polio workers to develop solutions for improving campaigns and identifying potential livelihood opportunities for them in the future.

For Amina and Salma, the conclusion of the February round meant that children under five had received the vaccine to build strong immunity against the poliovirus. However, the journey to eradication continues. After a short break, the programme will begin working on validating the next set of microplans. All of this work is essential to ensure that the virus really finds no place left to hide and no child left to paralyze.

By Rimsha Qureshi,
Communications Officer, GPEI Hub Amman

Islamabad – As he rode his motorbike out of the relative safety of Bannu city on a September morning, Danyal Sikandri was nervous. It was his first day on a new assignment, and he was riding out into the district outskirts with colleague Yasir Shah in search of a reclusive group of people – nomads.

Their task was to find nomadic settlements and vaccinate the children there against polio and other vaccine-preventable diseases. Sikandri has been involved with the Pakistan Polio Eradication Programme since 2019, first as vaccinator and then area in-charge. Therefore, he was no stranger to interacting with people. But with this assignment, he didn’t know what to expect, since he would be travelling long distances to find people who might not speak the same language, might be unwelcoming or worse, he could end up in an area which may not be secure.

After travelling for about 36 kilometers, the team found a nomadic settlement in Domel. A group of families clustered together in makeshift tents made of plastic sheets and cloth. Sikandri approached the elders and explained why they were there. The nomads, who had come from Afghanistan and were temporarily camped in Domel, warmly welcomed the vaccinators in their midst.

As Sikandri vaccinated 14 children in the camp that day, his nervousness dissipated, and a resolve set in – to bring life-saving vaccines to as many nomadic children as he could.

“When I met them, I saw how different their lifestyle is, since they are constantly on the move and far from health facilities,” says Sikandri. “They want to protect their children from diseases too, so they are happy to see us. They tell us that it is the first time that vaccinators have come to their tents to vaccinate their children.”

Sikandri is one half of a two-member special mobile team which works under Pakistan Polio Programme’s latest initiative to reach segments of the population with polio and essential vaccines, which they would otherwise not have access to. The nomad vaccination initiative was launched in September 2022 in the seven endemic districts of southern Khyber-Pakhtunkhwa (KP) and expanded to four districts of Punjab neighboring these districts in October. The initiative was further expanded to include more districts from Punjab in January and Balochistan in early March. A total of 80 mobile teams in 22 districts have been deployed so far to reach nomadic children.

“With this initiative, we are filling a crucial gap. In the past, we were vaccinating children on the move, in buses, on train stations and other transit points, but the children that were being left out were from nomadic populations. This initiative is a product of extensive research, where we mapped out population movements and based on that information, made mobile vaccination teams to reach nomadic children with polio as well as all essential immunization necessary for their health and safety,” said Dr Zainul Abedin Khan, the National Team Lead for WHO’s Polio Operations in Pakistan.

“This is an excellent initiative of the Government of Pakistan, with support of polio partners, to protect children who had never been vaccinated before. This initiative will keep expanding based on the movement patterns. With this, we hope that population immunity is increased, and poliovirus is interrupted permanently,” he added.

“They want to protect their children from diseases too, so they are happy to see us. They tell us that it is the first time that vaccinators have come to their tents to vaccinate their children.”

Since nomads are highly mobile, the children in these communities are missed during routine vaccination campaigns or even at transit vaccination sites because they may not be passing through formal routes. This means their immunity remains weak, they are vulnerable to disease and can potentially transmit poliovirus as they travel across country and district borders.

In 2022, the program conducted a comprehensive survey of nomadic movement patterns in February and March in 14 districts of KP, Punjab and Balochistan. The survey found that nomadic movement begins in southern KP in September and ends in March, with the nomads setting up temporary camps as they pass through various districts.

“It is difficult for our door-to-door vaccination teams to reach them since a majority of nomads live on district borders or peripheries and it is not even known when they are coming,” said Muhammad Asif Javaid, who leads the program’s High-Risk and Mobile Population Unit (HRMU) and is spearheading this initiative. “They are frequently on the move, staying in places temporarily, never settling, so they miss the opportunity to receive polio and routine immunization.”

In the first phase of implementation, two special mobile teams – consisting of a trained vaccinator and a team assistant – were deployed in each of the seven districts of southern KP and four districts of Punjab. Subsequently, the project was expanded to cover 22 districts of the country.

Union council staff collect data on nomads visiting their areas. This information along with weekly micro-plans and targets are provided to vaccinators, who travel across their assigned UCs to visit these settlements. They provide polio and other essential vaccinations to children in the camps and issue vaccination cards to the families to ensure the data remains on record.

Javaid said that these teams are also helping with surveillance for cases of acute flaccid paralysis (AFP) by asking families and looking for any children who might have AFP, and then ensuring that it is reported to relevant authorities for further testing.

As of March 31, more than 114,600 children under the age of five had received the oral polio vaccine, 71,206 had received the inactivated polio vaccine, while nearly 20,000 routine immunization antigens have been administered to eligible children, under this initiative.

“Currently the program is actively working to vaccinate chronically missed children and is focusing on reaching missed populations rather than prioritizing geography alone,” Dr Zainul Abedin Khan added.

The task is challenging for vaccinators, who travel many kilometers out of urban centers to find nomadic settlements. They might run out of fuel, the settlement might have packed up and left by the time they arrive, or they may encounter hostility, but the vaccinators take it in their stride, happy to be safeguarding children’s futures.

For Sikandri, the experience has been rewarding. He has seen areas of his native district now that he had never seen before, and he feels his communication skills have improved since he began working on this project.

“We have received a lot of love from these people. When we vaccinate their children, they are thankful and pray for us. It feels good that people like them and their children are also being taken care of,” said Sikandri.

By Suzanna Masih,
Communications Officer, WHO Pakistan (Video by NEOC)

Around the time when the Fédération Internationale de Football Association (FIFA) World Cup tournament was introduced, in 1930, children didn’t have access to polio vaccines. Additionally, systems to search for polio symptoms in children were most likely weak across the world. This scenario has changed now.

To prepare for an estimated 1.2 million football fans congregating in Qatar to watch the World Cup tournament, the Government of Qatar took several measures to mitigate risks associated with the spread of diseases, including polio. As part of these interventions, the country requested the World Health Organization (WHO) for technical support to assess and improve surveillance for polio.

Taking stock of existing disease surveillance systems

To kick off these efforts, after months of joint planning and coordination, a team from WHO’s Eastern Mediterranean Region (EMR) visited Qatar at the end of September 2022 to conduct an elaborate review of the surveillance system for acute flaccid paralysis (AFP). They examined activities at four main health care facilities − where both Qataris and visitors in the country frequently visit − to assess their contribution to AFP surveillance.

The team also conducted a virtual capacity development session for more than 200 public and private health professionals to understand the global and regional polio situation, and the importance of AFP surveillance and case reporting.

Reviewing systems to detect and respond to polio cases

On noting the recent spread of polioviruses across the world, and ease with which viruses can be transmitted, WHO sensitized officials at the Ministry of Public Health on the standard operating procedures for polio outbreaks. This includes a template to develop a national preparedness plan for a polio outbreak.

As next steps, the team conducted a Polio Outbreak Simulation Exercise (POSE), to test the level of preparedness and the blueprint of activities that should be conducted in case of an outbreak. The POSE ensures users are aware of activities to conduct within the crucial first 72 hours of confirmation of a polio outbreak. This exercise also aimed to ensure all existing tools in use are valid, and refreshed health officials’ knowledge on the different kinds of polioviruses that exist and vaccines that can be used to boost immunity.

Need to strengthen AFP case notification

One of the most highly developed countries in the EMR, Qatar has a state-of-the-art online health client database, which is used by 90 percent of health service providers. The country also uses unique codes for all residents regardless of their nationality, which helps them manage infectious disease outbreaks. Health facilities offer high quality of health care, which encourages communities’ uptake in health services. Taking this into account, the surveillance review revealed that the electronic health system in Qatar is able to track AFP cases once notified.

The country, however, faces challenges in the notification of AFP cases, largely due to the lack of a comprehensive list of diseases related to AFP in the electronic databases currently in use in health facilities and hospitals. Additionally, physicians lack awareness about AFP and case notification, which is attributed to Qatar being polio-free since 1990.

Recommendations for stronger surveillance of polio

Recommendations made by WHO to the Ministry of Public Health are aimed at developing the capacity of staff to notify AFP cases early; conduct regular active search for children with AFP, including through active surveillance visits; and execute 60-day follow up examination for AFP cases. The WHO team also advised Qatar to maintain updated and functional AFP surveillance guidelines, and a national preparedness and response plan for polio outbreaks and response.

WHO also encouraged the Ministry of Public Health to set up a system for environmental surveillance to search for polioviruses in sewage and wastewater at prime sites across the country. This would help to cast a wider net to search for any poliovirus both in visitors and communities living in the country.

Qatar plays a key role in polio eradication

The Government of Qatar is a key partner in polio eradication efforts. Qatar’s Minister of Public Health, HE Dr Hanan Mohamed Al Kuwari has been serving as the co-chair of the Regional Subcommittee for Polio Eradication and Outbreaks in the Eastern Mediterranean Region since February 2022. In this capacity,
HE Dr Al Kuwari has been instrumental in shining the spotlight on the current status of polio in the Region and efforts needed to end polio by the end of 2023.

Yemen is currently experiencing twin outbreaks of circulating vaccine-derived poliovirus type 1 and type 2 (cVDPV1 and cVDPV2). Both strains of poliovirus emerge in populations with low immunity and both can result in lifelong paralysis and even death.

Since 2019, 35 and 14 children have been paralysed by cVDPV1 and cVDPV2 respectively, three of the cVDPV2 cases confirmed in the past 10 days alone. The cVDPV2 outbreak, in particular, is ongoing and expanding and has already spread to other countries in WHO’s Eastern Mediterranean Region and UNICEF’s Middle East and North Africa Region. At its fourth meeting on 9 February 2022, the Eastern Mediterranean Ministerial Regional Subcommittee on Polio Eradication and Outbreaks issued a statement, expressing deep concern around these expanding outbreaks and requesting all authorities in Yemen to facilitate resumption of house-to-house vaccination campaigns in all areas.

The Global Polio Eradication Initiative (GPEI) partners strongly recommend high-coverage mass vaccination campaigns to stop a cVDPV outbreak. The vaccination response must achieve at least 90% of children vaccinated repeatedly with polio vaccine to protect them from polio and prevent seeding new vaccine-derived emergences. Therefore, the guidelines in the Polio Outbreak Response Standard Operating Procedures recommend that the vaccination response to polio outbreaks should be conducted using the house-to-house vaccine delivery strategy to maximize coverage of vulnerable children.

The GPEI urges the health authorities in Sana’a to conduct high quality house-to-house vaccination campaigns to stop the two concurrent outbreaks as soon as possible. If the current conditions in parts of Yemen do not permit house-to-house vaccination, then an intensified fixed-site vaccination campaign with appropriate social mobilization by the community and religious leaders trusted by the local communities should be implemented to maximize coverage among all vulnerable children.

Yemeni children face no shortage of threats: prolonged conflict, a devastated healthcare system, hunger and disease. But polio is one disease that can easily be prevented. Its circulation can be stopped in Yemen or anywhere else by vaccinating all children with oral polio vaccine.

The GPEI partners – WHO, Rotary International, the U.S. Centers for Disease Control and Prevention, UNICEF, the Bill & Melinda Gates Foundation and Gavi – are committed to providing support to all stakeholders in Yemen for responding to the polio outbreaks including in conducting polio vaccination campaigns that can reach all vulnerable children.

Boy receiving polio drops from a health worker, with his mother during a polio vaccination campaign in 2015. © WHO / Alex Shpigunov

A poliomyelitis (polio) vaccination campaign for children aged 6 months to 6 years who missed routine polio doses in the past will begin in Ukraine on 1 February 2022. This catch-up campaign is part of a comprehensive response to stop an outbreak of poliovirus first detected in Ukraine in October 2021. This first stage will last 3 weeks and is expected to reach nearly 140 000 children throughout the country.

Years of low immunization coverage in Ukraine have created a large pool of unvaccinated or under-vaccinated children who are vulnerable to polio. While routine immunization coverage has gradually increased over the past 6 years, in 2020, only 84% of 1-year-olds received the required 3 scheduled doses of polio vaccines by 12 months of age.

The immediate goal of the campaign is to reach the WHO-recommended level of 95% vaccination coverage of eligible children.

Background

The polio outbreak in Ukraine was confirmed on 6 October 2021. Poliovirus (circulating vaccine-derived poliovirus type 2) was first isolated in a 17-month-old girl in the province of Rivne who developed acute flaccid paralysis. Analysis of all her contacts found that 7 household contacts (siblings) and 8 community contacts in Rivne as well as 4 cousins in the province of Zakarpattya (who had had contact with the girl’s siblings) also tested positive, but did not develop paralytic symptoms.

A second case with acute flaccid paralysis (a 2-year-old boy in the region of Zakarpattya) also tested positive for poliovirus, with onset of paralysis in December 2021.

The isolated strain of the virus found in both paralytic cases and their contacts is linked to a poliovirus in Pakistan, which was also the cause of several cases in Tajikistan in 2020–2021.

Comprehensive plan to stop the spread of poliovirus

Following an initial local vaccination campaign, conducted where the first case was detected, a comprehensive polio outbreak response plan was approved by the Ministry of Health in December 2021.

The first stage of the plan will provide inactivated polio vaccine (IPV) to children aged 6 months to 6 years who have not received the required number of doses. In the second stage, all children under the age of 6 will be vaccinated with oral polio vaccine (OPV), even if they have received all their scheduled vaccination doses. This is necessary to protect children from infection and to stop the circulation of the virus. Dates for the second stage are pending.

In November:

No case of WPV1 was confirmed
35 million children were vaccinated during the MR Campaign in November 2021.
1 million children were vaccinated at 73 Permanent Transit Points

In October:

No case of WPV1 was confirmed
3.53 million children were vaccinated during October 2021 in KP outbreak response.
0.6 million children were vaccinated at 73 Permanent Transit Points

On 31 May, Tajikistan started a supplement immunization campaign against poliomyelitis to vaccinate all children under the age of six with two doses of oral polio vaccine. ).

Poliomyelitis (polio) returned to Tajikistan in the past year, with the first case of an outbreak of circulating vaccine-derived poliovirus type 2 (cVDPV2) detected in a child who developed acute flaccid paralysis (AFP) on 22 November 2020 in the province of Khatlon.

In response to the outbreak, 3 rounds of supplementation immunization with novel oral polio vaccine type 2 (nOPV2) were conducted, all of which reached a reported 99% of the target group of children under the age of 6.

Both environmental surveillance and active AFP case searches in hospitals and health facilities are continuing throughout the country to ensure that any potential further circulation will be detected.

The latest AFP case with confirmed cVDPV2 had onset of paralysis on 26 June 2021. The latest positive environmental sample was collected on 27 August, before completion of the third round of immunization in early September.

“Tajikistan has responded with full commitment and with the dedicated support of Global Polio Eradication Initiative partners to stop this outbreak,” said Dr Victor Olsavszky, WHO Representative and Head of the WHO Country Office in Tajikistan.

“We are cautiously optimistic that the extensive surveillance and immunization campaigns of the past 11 months have closed the door on further spread of this virus. This is vital for the health of children in Tajikistan and beyond.”

Extent of the outbreak in Tajikistan

As of 1 October 2021, 31 children have been found to have polio (paralysis) caused by cVDPV2, and the virus has also been isolated from 26 children without paralysis. Twenty environmental samples have tested positive for presence of the virus. All detected polioviruses are linked to a virus strain currently circulating in Pakistan.

The geographic spread of cVDPV2 (based on detection among children and in the environment) has been limited to Dushanbe city and 14 districts in the centre and south of the country.

Background

The oral polio vaccine (OPV) that has brought the wild poliovirus to the brink of eradication has many benefits: the live attenuated (weakened) vaccine virus provides better immunity in the gut, which is where polio replicates.

However, in communities with low immunization coverage, as the virus is spread from one unvaccinated child to another over a long period of time (often 12–18 months), it can mutate into a form that can cause paralysis, just like the wild poliovirus. This mutated poliovirus can then spread in communities, leading to cVDPV2 outbreaks.

The number of cVDPV2 outbreaks globally has increased sharply since early 2019. In 2020, cVDPV2 cases emerged in Afghanistan and were reported in areas close to Tajikistan, Turkmenistan and Uzbekistan.

nOPV2 is a new tool that Global Polio Eradication Initiative partners are deploying to better address cVDPV2. nOPV2 is safe and provides comparable protection against poliovirus, while being more genetically stable and therefore less likely to revert into a form that can cause paralysis in under-immunized communities. This means that nOPV2 could help stop cVDPV2 outbreaks.

WHO recommends that all countries, in particular those in which there is frequent travel to and contact with polio-affected countries and areas, strengthen surveillance for AFP and maintain high routine immunization coverage. All travellers to polio-affected areas should be fully vaccinated against polio.

In September:

No new Wild Poliovirus (WPV1) case and no new cVDPV2 cases were confirmed.
809 981 children were vaccinated against polio

In September:

No case of WPV1 was confirmed
41.5 million children were vaccinated during NIDs.
0.8 million children were vaccinated at 72 Permanent Transit Points

In August:

No case of WPV1 was confirmed
23.4 million children were vaccinated during sNIDs.
1 million children were vaccinated at 121 Permanent Transit Points

In July:

No case of WPV1 was confirmed
1,2 million children were vaccinated at 121 Permanent Transit Points

In May:

No new Wild Poliovirus (WPV1)cases and 5 new cVDPV2 cases were confirmed.
712,739 children were vaccinated against polio

In May:

No case of WPV1 was confirmed
900,000 children were vaccinated at 121 Permanent Transit Points

In April:

No new Wild Poliovirus (WPV1)cases and 5 new cVDPV2 cases were confirmed.
679,355 children were vaccinated against polio

Children wait to be vaccinated as part of national polio vaccination campaign in Mogadishu. © Siyaad Mohamed /Ildoog/ WHO SOMALIA

Dr Hamid Jafari, Director of Polio Eradication for WHO’s Eastern Mediterranean Region, declared Somalia’s outbreak of circulating vaccine-derived poliovirus type 3 (cVDPV3) closed a full 28 months after this strain of polio was last detected in Somalia.

Seven children were paralysed by the type 3 strain in the 2018 outbreak, and sewage samples regularly monitored for poliovirus tested positive for cVDPV3 a dozen times, beginning March 2018. There is no doubt that the virus circulated widely around southern and central Somalia. Despite extensive disease surveillance measures, no cVDPV3 has been identified since 7 September 2018, when the last child developed paralysis.

Closing a polio outbreak is a formal process steered by a detailed checklist of surveillance indicators that must be met in order to show that the virus is not just hiding in a far-flung pocket but has truly disappeared. Sewage runoff is tested for virus, and health workers and community members actively search for paralysis in children, and then investigate any paralysis they do find to rule out polio. Accessing hard-to-reach communities is a challenge in Somalia, but a vital aspect of this work.

The 2018 cVDPV3 outbreak was part of a 2-strain polio outbreak in Somalia at that time, along with circulating vaccine-derived poliovirus type 2. Both strains emerge and paralyse children in under-immunized populations – places where not enough children have consistently had access to polio vaccines. The cVDPV2 outbreak continues to paralyse children, and environmental samples – sewage water – consistently show that virus moving through Somali communities. For the polio programme, the presence of cVDPV2 samples and the absence of cVDPV3 samples is bittersweet: it demonstrates the sensitivity of our testing, so we can be confident cVDPV3 is no longer a threat to Somali children – but it makes clear that the threat of paralytic polio still looms.

Across the Region, cVDPV2 cases are on the rise – as across much of WHO’s African Region. Wild poliovirus still stalks children across Afghanistan and Pakistan, and the movement of people across borders underscores the risk of importation across and beyond the Region.

The end of Somalia’s cVDPV3 outbreak shows what can be achieved with high-quality vaccination campaigns, on-the-ground leadership and sensitive surveillance measures.