Poliovirus – GPEI
Poliovirus

Polio paralysis is caused by a human enterovirus called the wild poliovirus. It can interact in its host in two ways:

  • Infection not including the central nervous system, which causes a minor illness with mild symptoms
  • Infection including the central nervous system, which may cause paralysis

Less than 1% of wild poliovirus infections result in paralysis. The virus is most often spread by the faecal-oral route. It enters through the mouth and multiplies in the intestine. Infected individuals shed poliovirus into the environment for several weeks, where it can spread rapidly through a community, especially in areas of poor sanitation.

There are two forms of poliovirus:

Wild Polioviruses

Variant Polioviruses

Testing for polioviruses

All cases of acute flaccid paralysis (AFP) among children under fifteen years of age are reported and tested for wild poliovirus or vaccine-derived polioviruses within 48 hours of onset. AFP is caused by a range of factors. The Global Polio Laboratory Network tests upwards of 100,000 AFP samples a year, of which a very small portion are positive for poliovirus.