Clinical Trials and Seroprevalence Surveys
The research team at GPEI supports a range of clinical trials and seroprevalence surveys that help to advise the eradication programme. The partners provide technical assistance, working in collaboration with institutes including PATH, academic institutions, national institutes for public health and national regulatory authorities.
On-going clinical trials principally evaluate the immunogenicity and safety of newly developed vaccines, new devices for vaccine administration and alternative vaccine schedules. We also support trials that target key scientific questions to provide scientific rationale to drive future global policy.
Recent clinical trial publications:
Resik et al. (2015) ‘Immune responses after fractional doses of inactivated poliovirus vaccine using newly developed intradermal jet injectors: a randomized controlled trial in Cuba’ Vaccine 33(2)
Sutter et al. (2015) ‘Needle-free jet injector intradermal delivery of fractional dose inactivated poliovirus vaccine: Association between injection quality and immunogenicity’ Vaccine 33(43)
Aylward et al. (2015) ‘Immunogenicity of a new routine vaccination schedule for global poliomyelitis prevention: an open-label, randomised controlled trial’ Lancet 386
Sutter et al. (2015) ‘Decay of Sabin inactivated poliovirus vaccine (IPV)-boosted poliovirus antibodies’ Trials in Vaccinology 4
Aylward et al. (2014) ‘Efficacy of inactivated poliovirus vaccine in India’ Science 345
Over the years the programme has supported the implementation of periodic seroprevalence surveys as a tool to evaluate program performance and to understand the risk of poliovirus spread. These were implemented in endemic and high risk countries, such as Pakistan, Nigeria and India, as well as in other programmatically important areas such as Sri Lanka, Madagascar, West Africa and others. Recent publications presented below.
Recent seroprevalence survey publications:
Vaz et al. (2016) ‘Role of Serial Polio Seroprevalence Studies in Guiding Implementation of the Polio Eradication Initiative in Kano, Nigeria: 2011–2014’ J. Infect Dis. 213 Suppl 3
Zaidi et al. (2015) ‘Immunogenicity of poliovirus vaccines in chronically malnourished infants: A randomized controlled trial in Pakistan’ Vaccine 33(24)
Sutter et al. (2015) ‘Achieving high seroprevalence against polioviruses in Sri Lanka—Results from a serological survey, 2014’ Journal of Epidemiology and Global Health 5(4)
Deshpande et al. (2014) Cross-sectional Serologic Assessment of Immunity to Poliovirus Infection in High-Risk Areas of Northern India’ J Infect Dis. 210 (Suppl 1)
Sutter et al. (2012) ‘Survey of poliovirus antibodies in Kano, Northern Nigeria’ Vaccine 32 (12)